Lhcgr^tm1Hht
Targeted Allele Detail

Summary

• Symbol: Lhcgr^tm1Hht
• Name: luteinizing hormone/choriogonadotropin receptor; targeted mutation 1, Ilpo Huhtaniemi
• MGI ID: MGI:2181999
• Synonyms: LHR -, LuRKO
• Gene: Lhcgr Location: Chr17:89023909-89099418 bp, - strand Genetic Position: Chr17, 58.35 cM
• Alliance: Lhcgr^tm1Hht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66818
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 11, which encodes the transmembrane and cytoplasmic receptor domains, was replaced with a neomycin selection gene by homologous recombination. RT-PCR analysis demonstrated that no full length transcript was made in homozygous mice. Radioimmunoassays confirmed that no functional protein was present in homozygous mice. (J:66818)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lhcgr Mutation: 43 strains or lines available

References

• Original: J:66818 Zhang FP, et al., Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol Endocrinol. 2001 Jan;15(1):172-83
• All: 18 reference(s)