Pten^tm2Mak
Targeted Allele Detail

Summary

• Symbol: Pten^tm2Mak
• Name: phosphatase and tensin homolog; targeted mutation 2, Tak W Mak
• MGI ID: MGI:2182005
• Synonyms: PTEN^Co, Pten^f, Pten^fl, Pten^flox, Pten^L, Pten^loxP
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm2Mak page

Urothelial hyperplasia and increased apoptosis in bladder epithelium of Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69471
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted in intron 3 and a floxed hygromycin selection cassette was inserted in intron 5. The hygromycin selection cassette was removed in ES cells by transient Cre expression, leaving exons 4 and 5 flanked by loxP sites in the final allele. (J:69471)

Disease models

Expression

In Mice Carrying this Mutation:	68 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	46 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm2Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:69471 Suzuki A, et al., T cell-specific loss of pten leads to defects in central and peripheral tolerance. Immunity. 2001 May;14(5):523-34
• All: 256 reference(s)