Mesp1^tm3Ysa
Targeted Allele Detail

Summary

• Symbol: Mesp1^tm3Ysa
• Name: mesoderm posterior 1; targeted mutation 3, Yumiko Saga
• MGI ID: MGI:2182080
• Synonyms: Mesp1(-), Mesp1-null
• Gene: Mesp1 Location: Chr7:79441989-79443338 bp, - strand Genetic Position: Chr7, 45.16 cM
• Alliance: Mesp1^tm3Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49903
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Exons 1 and 2 were disrupted by the insertion of a PGK-neo cassette. (J:49903)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mesp1 Mutation: 18 strains or lines available

Notes

Chimera analysis in which double homozygous Mesp1^tm3Ysa and Mesp2^tm3(cre)Ysa mutant embryos were aggregated with wild-type embryos show that embryos develop normally, however double knock-out cells are scarcely seen in the anterior-cephalic and heart mesoderm, but they do contribute to the formation of somites, notochord, and gut, and the atrial appendage is exclusively composed of the mutant cells (J:62984).

References

• Original: J:49903 Saga Y, Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement. Mech Dev. 1998 Jul;75(1-2):53-66
• All: 4 reference(s)