Lta4h^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Lta4h^tm1Bhk
• Name: leukotriene A4 hydrolase; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:2182082
• Synonyms: LtA4 hydrolase^-
• Gene: Lta4h Location: Chr10:93289273-93320737 bp, + strand Genetic Position: Chr10, 48.42 cM, cytoband C3
• Alliance: Lta4h^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58985
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced 114 base pairs of coding sequence. Northern blot analysis of total RNA showed an absence of transcript in bone marrow and bone marrow mast cells, both obtained from homozygous mutant mice. (J:58985)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lta4h Mutation: 34 strains or lines available

References

• Original: J:58985 Byrum RS, et al., Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. J Immunol. 1999 Dec 15;163(12):6810-9
• All: 15 reference(s)