Slc2a4^tm1Abel
Targeted Allele Detail

Summary

• Symbol: Slc2a4^tm1Abel
• Name: solute carrier family 2 (facilitated glucose transporter), member 4; targeted mutation 1, E Dale Abel
• MGI ID: MGI:2182083
• Synonyms: AG4KO, G4H - (cre lox), GLUT4 lox
• Gene: Slc2a4 Location: Chr11:69833365-69839014 bp, - strand Genetic Position: Chr11, 42.93 cM, cytoband C-E1
• Alliance: Slc2a4^tm1Abel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59054
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exon 10, which encodes the external and internal glucose binding sites. A neomycin selection cassette was also inserted downstream of the final coding exon. (J:59054)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a4 Mutation: 35 strains or lines available

References

• Original: J:59054 Abel ED, et al., Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest. 1999 Dec;104(12):1703-14
• All: 22 reference(s)