Tg(Ckmm-cre)5Khn
Transgene Detail

Summary

• Symbol: Tg(Ckmm-cre)5Khn
• Name: transgene insertion 5, C Ronald Kahn
• MGI ID: MGI:2182095
• Synonyms: Ckm-cre, Ckmm-cre, Ckmm-NLS-cre, Cre^Mck, mckCRE, MCK-cre, MCKCre⁺, MCK-cre5, Tg(Ckm-cre)5Khn, Tg(Ckmm-cre)1Khn
• Transgene: Tg(Ckmm-cre)5Khn Location: unknown
• Alliance: Tg(Ckmm-cre)5Khn page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Ckmm-cre)5Khn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Ckm

• Mutation details: A 6.5 kb genomic DNA fragment of the Ckmm gene containing the promoter and enhancer 1, untranslated exon 1, 3kb of intron 1 including the enhancer 2 region, and the first 16 bp of exon 2 drives expression of a modified cre with an SV40 large T antigen nuclear localization signal. Expression is directed to the heart and skeletal muscle. (J:51266)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ckm (species not specified) Summary of all recombinase alleles driven by Ckm. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

440 assay results 20 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

References

• Original: J:51266 Bruning JC, et al., A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell. 1998 Nov;2(5):559-69
• All: 396 reference(s)