Sox4^tm2Cle
Targeted Allele Detail

Summary

• Symbol: Sox4^tm2Cle
• Name: SRY (sex determining region Y)-box 4; targeted mutation 2, Hans Clevers
• MGI ID: MGI:2182108
• Synonyms: Tg2001
• Gene: Sox4 Location: Chr13:29132902-29137682 bp, - strand Genetic Position: Chr13, 12.87 cM, cytoband A3-A5
• Alliance: Sox4^tm2Cle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32741
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct containing a neomycin selection cassette in the opposite orientation and lacking a start codon replaced the 5' region of the gene. Northern blot analysis showed an absence of transcript in the heads of homozygous mutant embryos. (J:32741)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox4 Mutation: 23 strains or lines available

References

• Original: J:32741 Schilham MW, et al., Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature. 1996 Apr 25;380(6576):711-4
• All: 1 reference(s)