Npy^tm1Rpa
Targeted Allele Detail

Summary

• Symbol: Npy^tm1Rpa
• Name: neuropeptide Y; targeted mutation 1, Richard D Palmiter
• MGI ID: MGI:2182113
• Synonyms: Npy-
• Gene: Npy Location: Chr6:49799690-49806487 bp, + strand Genetic Position: Chr6, 24.04 cM, cytoband B3
• Alliance: Npy^tm1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33261
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which encodes the signal peptide and 35 amino acids, was replaced by a lacZ-neo fusion gene. The expression pattern of the beta-galactosidase was shown to resemble that of the endogenous gene via comparisons of X-gal staining and previous in situ hybridization studies. RT-PCR analysis of brain tissue showed an absence of transcript in homozygous mutant mice. (J:33261)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npy Mutation: 19 strains or lines available

References

• Original: J:33261 Erickson JC, et al., Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y [see comments]. Nature. 1996 May 30;381(6581):415-21
• All: 76 reference(s)