Tg(CMV-Scnn1a)1352Rss
Transgene Detail

Summary

• Symbol: Tg(CMV-Scnn1a)1352Rss
• Name: transgene insertion 1352, Bernard C Rossier
• MGI ID: MGI:2182126
• Transgene: Tg(CMV-Scnn1a)1352Rss Location: unknown
• Alliance: Tg(CMV-Scnn1a)1352Rss page

Transgene origin

• Strain of Origin: NMRI

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-Scnn1a)1352Rss expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Scnn1a (25122)

  Scnn1a

  (MGI:101782)

• Mutation details: The transgene consists of a constituitive and ubiquitous cytomegalovirus promoter, an IgE intron, the rat Scnn1a (alpha ENaC; position -78 to +2149), and simian virus 40 large T antigen polyadenylation sequences. RT-PCR showed reconstitution of expression of the transgene in lung, kidney, skin, and colon tissue. Expression analysis of cardiac tissue showed that Scnn1a transcript is absent in wild-type mice and present in the transgenic mice. Transcript was undetected in liver tissue isolated from wild-type and transgenic mice. Reconstitution was additionally confirmed in lung tissue via in situ hybridization. (J:43583)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:43583 Hummler E, et al., A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11710-5
• All: 5 reference(s)