Ctsk^tm1Psa
Targeted Allele Detail

Summary

• Symbol: Ctsk^tm1Psa
• Name: cathepsin K; targeted mutation 1, Paul Saftig
• MGI ID: MGI:2182131
• Synonyms: Cathk^-, CatK^-, K^-
• Gene: Ctsk Location: Chr3:95406567-95416673 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Ctsk^tm1Psa page

Radiographs and histological analysis of Ctsk^tm1Psa/Ctsk^tm1Psa mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50934
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 7. An absence of transcript generated from this allele was determined by Northern blot and RT-PCR analyses of total bone RNA. Western blot analysis of protein extracts from homozygous mutant bone showed a lack or encoded protein. (J:50934)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctsk Mutation: 31 strains or lines available

References

• Original: J:50934 Saftig P, et al., Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13453-8
• All: 30 reference(s)