Ctss^tm1Eae
Targeted Allele Detail

Summary

• Symbol: Ctss^tm1Eae
• Name: cathepsin S; targeted mutation 1, Eileen A Elliot
• MGI ID: MGI:2182132
• Synonyms: catS^-
• Gene: Ctss Location: Chr3:95434097-95463714 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Ctss^tm1Eae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53399
• Parent Cell Line: DBA-252 (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a 3.0kb region containing the active site residue. Functional ablation of the protein product in homozygous mutant mice was determined via an active-site labeling assay of splenocytes and LPS B cell blasts. (J:53399)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctss Mutation: 32 strains or lines available

Notes

The author (Renee LeBoeuf) has confirmed that the allele used in the reference J:153355 was incorrectly reported as Ctss^tm1Hap; the correct allele is Ctss^tm1Eae .

References

• Original: J:53399 Nakagawa TY, et al., Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity. 1999 Feb;10(2):207-17
• All: 5 reference(s)