Ctss^tm1Hap
Targeted Allele Detail

Summary

• Symbol: Ctss^tm1Hap
• Name: cathepsin S; targeted mutation 1, Harold A Chapman
• MGI ID: MGI:2182133
• Synonyms: catS^-
• Gene: Ctss Location: Chr3:95434097-95463714 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Ctss^tm1Hap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53799
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5, encoding the active site cysteine, was replaced with a neomycin selection cassette. Western blot analysis showed an absence of encoded protein in splenocyte and dendritic cell lysates derived from homozygous mutant mice. (J:53799)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ctss Mutation: 32 strains or lines available

References

• Original: J:53799 Shi GP, et al., Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity. 1999 Feb;10(2):197-206
• All: 44 reference(s)