Npm2^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Npm2^tm1Zuk
• Name: nucleophosmin/nucleoplasmin 2; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:2182141
• Synonyms: Npm2^-
• Gene: Npm2 Location: Chr14:70884742-70896684 bp, - strand Genetic Position: Chr14, 36.42 cM
• Alliance: Npm2^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83658
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 (including the ATG initiation codon), exon 3 and the splice acceptor junction of exon 4 were replaced with a Pgk-HPRT expression cassette. Homozygous mutant ovaries lacked NPM2 protein as indicated by immunohistochemistry and Western blot analysis. (J:83658)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npm2 Mutation: 11 strains or lines available

References

• Original: J:83658 Burns KH, et al., Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science. 2003 Apr 25;300(5619):633-6
• All: 5 reference(s)