Ctsg^tm1.1Roes
Targeted Allele Detail

Summary

• Symbol: Ctsg^tm1.1Roes
• Name: cathepsin G; targeted mutation 1.1, Jurgen Roes
• MGI ID: MGI:2182170
• Synonyms: CG^-
• Gene: Ctsg Location: Chr14:56337342-56340031 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Ctsg^tm1.1Roes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77597
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Transient expression of cre recombinase in ES cells resulted in the excision of a floxed neomycin cassette and a deletion spanning exons 2, 3, and part of 4. Northern and Western blot analyses of bone marrow cells showed an absence of transcript and protein in homozygous mutant mice. (J:77597)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Ctsg Mutation: 13 strains or lines available

References

• Original: J:77597 Tkalcevic J, et al., Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity. 2000 Feb;12(2):201-10
• All: 7 reference(s)