Vdac3^tm1Wjc
Targeted Allele Detail

Summary

• Symbol: Vdac3^tm1Wjc
• Name: voltage-dependent anion channel 3; targeted mutation 1, Willam J Craigen
• MGI ID: MGI:2182182
• Synonyms: VDAC3(-)
• Gene: Vdac3 Location: Chr8:23067102-23083774 bp, - strand Genetic Position: Chr8, 11.42 cM
• Alliance: Vdac3^tm1Wjc page

Structural abnormalities in sperm of Vdac3^tm1Wjc/Vdac3^tm1Wjc male mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72188
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The last four exons were replaced with a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via Northern blot analysis of various tissues. The absence of protein in homozygous mutant mice was demonstrated by Western blot analysis of various tissues and immunohistochemical staining of the testes. (J:72188, J:78058)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdac3 Mutation: 19 strains or lines available

References

• Original: J:72188 Sampson MJ, et al., Immotile sperm and infertility in mice lacking mitochondrial voltage-dependent anion channel type 3. J Biol Chem. 2001 Oct 19;276(42):39206-12
• All: 7 reference(s)