Il6^tm1Mur
Targeted Allele Detail

Summary

• Symbol: Il6^tm1Mur
• Name: interleukin 6; targeted mutation 1, Richard Murray
• MGI ID: MGI:2182222
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^tm1Mur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25684
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced approximately 95% of exon 4. ELISA, both in vitro of thymic stromal cell supernatants stimulated by LPS and in vivo of sera from LPS stimulated animals, showed a lack of encoded protein in homozygous mutant mice. (J:25684)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 38 strains or lines available

References

• Original: J:25684 Dalrymple SA, et al., Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect Immun. 1995 Jun;63(6):2262-8
• All: 12 reference(s)