Lta/Tnf^tm1Eug
Targeted Allele Detail

Summary

• Symbol: Lta/Tnf^tm1Eug
• Name: lymphotoxin A; targeted mutation 1, Hans-Pietro Eugster
• MGI ID: MGI:2182272
• Synonyms: TNF-LTalpha-, TNF/LTalpha-, tnf/ltatm1
• Gene: Lta Location: Chr17:35422141-35424327 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Lta/Tnf^tm1Eug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31129
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The insertion of a single neomycin selection cassette deleted exons 2 and 3 of the Lta locus and exon 1 through the middle of exon 4 of the Tnf locus. (J:31129)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	B6.129-Lta/Tnf^tm1Eug
hm2	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	involves: 129
hm3	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	involves: 129 * C57BL/6J
hm4	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	involves: 129/Sv * C57BL/6

Phenotypes:

Affected Systems	hm1	hm2	hm3	hm4
show or hide all annotated terms
behavior/neurological	√
abnormal sleep pattern	√
cardiovascular system			√
increased heart weight			√
cellular	√
impaired macrophage phagocytosis	√
growth/size/body			√
increased heart weight			√
increased body mass index			√
increased body weight			√
increased body length			√
increased susceptibility to diet-induced obesity			√
enlarged liver			√
increased liver weight			√
increased spleen weight			√
hematopoietic system	√	√	√
impaired macrophage phagocytosis	√
decreased T cell number		√
increased leukocyte cell number		√
increased B cell number		√
abnormal spleen morphology		√
increased spleen weight			√
abnormal spleen marginal zone morphology		√
decreased IgA level		√
decreased IgG1 level	√
decreased IgG2a level	√
decreased IgG3 level	√
increased IgM level	√
homeostasis/metabolism	√		√	√
increased susceptibility to diet-induced obesity			√
decreased circulating interferon-gamma level	√
increased susceptibility to injury				√
immune system	√	√	√	√
impaired macrophage phagocytosis	√
decreased T cell number		√
increased leukocyte cell number		√
increased B cell number		√
abnormal spleen morphology		√
increased spleen weight			√
abnormal spleen marginal zone morphology		√
decreased circulating interferon-gamma level	√
absent Peyer's patches		√
absent lymph nodes		√
abnormal humoral immune response		√
decreased IgA level		√
decreased IgG1 level	√
decreased IgG2a level	√
decreased IgG3 level	√
increased IgM level	√
decreased interferon-gamma secretion	√
decreased susceptibility to experimental autoimmune encephalomyelitis				√
decreased susceptibility to induced arthritis	√
increased susceptibility to bacterial infection	√
increased susceptibility to bacterial infection induced morbidity/mortality	√
decreased susceptibility to parasitic infection				√
increased susceptibility to parasitic infection		√
increased susceptibility to Poxviridae infection		√
increased susceptibility to Riboviria infection		√
limbs/digits/tail			√
long tibia			√
liver/biliary system			√
enlarged liver			√
increased liver weight			√
hepatic steatosis			√
mortality/aging	√	√		√
increased susceptibility to bacterial infection induced morbidity/mortality	√
decreased susceptibility to induced morbidity/mortality		√
increased susceptibility to induced morbidity/mortality		√		√
skeleton	√		√
decreased susceptibility to induced arthritis	√
long tibia			√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lta Mutation: 17 strains or lines available

References

• Original: J:31129 Eugster HP, et al., Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice. Int Immunol. 1996 Jan;8(1):23-36
• All: 35 reference(s)