Lta/Tnf^tm1Eug
Targeted Allele Detail

Summary

• Symbol: Lta/Tnf^tm1Eug
• Name: tumor necrosis factor; targeted mutation 1, Hans-Pietro Eugster
• MGI ID: MGI:2182273
• Synonyms: TNF-LTalpha-, TNF/LTalpha-, tnf/ltatm1
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Lta/Tnf^tm1Eug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31129
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The insertion of a single neomycin selection cassette deleted exons 2 and 3 of the Lta locus and exon 1 through the middle of exon 4 of the Tnf locus. (J:31129)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 48 strains or lines available

References

• Original: J:31129 Eugster HP, et al., Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice. Int Immunol. 1996 Jan;8(1):23-36
• All: 35 reference(s)