Nkx6-2^tm1Qiu
Targeted Allele Detail

Summary

• Symbol: Nkx6-2^tm1Qiu
• Name: NK6 homeobox 2; targeted mutation 1, Mengsheng Qiu
• MGI ID: MGI:2182286
• Synonyms: Nkx6.2-
• Gene: Nkx6-2 Location: Chr7:139159292-139162713 bp, - strand Genetic Position: Chr7, 84.57 cM
• Alliance: Nkx6-2^tm1Qiu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69975
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were deleted by the insertion of a neomycin selection cassette. RT-PCR analysis and in situ hybridization of embryonic midbrain showed an absence of transcript in homozygous mutant mice. The expression of Nkx6-1 was shown to be unaffected by the targeting event via in situ hybridization. (J:69975)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx6-2 Mutation: 17 strains or lines available

References

• Original: J:69975 Cai J, et al., Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally. Mol Cell Biol. 2001 Jul;21(13):4399-403
• All: 4 reference(s)