Dach1tm1Mrd
Targeted Allele Detail
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| Symbol: |
Dach1tm1Mrd |
| Name: |
dachshund family transcription factor 1; targeted mutation 1, Graeme Mardon |
| MGI ID: |
MGI:2182311 |
| Gene: |
Dach1 Location: Chr14:98024289-98407201 bp, - strand Genetic Position: Chr14, 48.25 cM, cytoband E3
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| Alliance: |
Dach1tm1Mrd page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:67361
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| Parent Cell Line: |
AB2.1 (ES Cell)
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| Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A genomic fragment encompassing 319 bp upstream of exon 1, exon 1, and approximately 2kb of intron 1 was replaced with a PGK-hprt cassette inserted by homologous recombination. The aberrant integration of additional sequence derived from the targeting vector was identified downstream of the 3' arm of homology. Whole mount in situ hybridization showed a lack of normal transcript in homozygous mutant mice. Immunohistochemical staining confirmed the absence of protein in the retina, the cornea, and retinal pigmented epithelium.
(J:67361)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Dach1 Mutation: |
51 strains or lines available
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| Original: |
J:67361 Davis RJ, et al., Dach1 mutant mice bear no gross abnormalities in eye, limb, and brain development and exhibit postnatal lethality. Mol Cell Biol. 2001 Mar;21(5):1484-90 |
| All: |
5 reference(s) |
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Analysis Tools
