Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}
Transgenic Allele Detail

Summary

• Symbol: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}
• Name: general transcription factor II I repeat domain-containing 1; transgene insertion 166.8, Snorri S Thorgeirsson
• MGI ID: MGI:2182322
• Synonyms: Alb-c-myc line 166.8, Alb/c-myc line 166.8, c-myc line 166.8, Gtf2ird1^-, Tg(Alb1-Myc)166.8Sst
• Gene: Gtf2ird1 Location: Chr5:134386510-134485570 bp, - strand Genetic Position: Chr5, 74.55 cM
• Alliance: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst} page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Hypomorph, Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Gtf2ird1^{Tg(Alb1-Myc)166.8Sst} expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)

• Mutation details: A transgene construct consisting of mouse Myc under the control of the mouse albumin promoter replaced of approximately 40 kb of chromosome 5, encompassing sequence downstream of Cyln2 through the first exon of Gtf2ird1. Northern blot and RT-PCR analysis of heart, muscle, liver, and spleen tissue from homozygous mutant mice showed highly reduced levels of Gtf2ird1 transcript. (J:4527, J:68983)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gtf2ird1 Mutation: 359 strains or lines available

Notes

Integration was mapped to a region on chromosome 5 that is orthologous to a human region hemizygously deleted in Williams-Beuren syndrome patients.

References

• Original: J:4527 Murakami H, et al., Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res. 1993 Apr 15;53(8):1719-23
• All: 31 reference(s)