Nr4a1^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Nr4a1^tm1Jmi
• Name: nuclear receptor subfamily 4, group A, member 1; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:2182325
• Synonyms: classical Nur77-KO, NGFI-B (-), NGFI-B^-, Nur77^-
• Gene: Nr4a1 Location: Chr15:101152150-101172676 bp, + strand Genetic Position: Chr15, 56.64 cM, cytoband F
• Alliance: Nr4a1^tm1Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77686
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin resistance gene 300 bp downstream of the translational start site. A functional portion of the N-terminal domain of the full length gene is expressed. (J:77686, J:270260)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Nr4a1 Mutation: 39 strains or lines available

References

• Original: J:77686 Lee SL, et al., Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77). Science. 1995 Jul 28;269(5223):532-5
• All: 116 reference(s)