Cysltr1^tm1Ykn
Targeted Allele Detail

Summary

• Symbol: Cysltr1^tm1Ykn
• Name: cysteinyl leukotriene receptor 1; targeted mutation 1, Yoshihide Kanaoka
• MGI ID: MGI:2182326
• Synonyms: CysLT1R-, Cys-LT1R KO
• Gene: Cysltr1 Location: ChrX:105617952-105647285 bp, - strand Genetic Position: ChrX, 47.36 cM, cytoband D
• Alliance: Cysltr1^tm1Ykn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77087
• Parent Cell Line: V26.2 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 278 bp coding region of exon 4 common to both the long and short isoforms of the gene was replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis verified the absence of gene expression in lung of homozygous mutant animals. (J:77087)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cysltr1 Mutation: 11 strains or lines available

References

• Original: J:77087 Maekawa A, et al., Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. J Biol Chem. 2002 Jun 7;277(23):20820-4
• All: 23 reference(s)