Dbx1^tm1Tmj
Targeted Allele Detail

Summary

• Symbol: Dbx1^tm1Tmj
• Name: developing brain homeobox 1; targeted mutation 1, Thomas M Jessell
• MGI ID: MGI:2182329
• Synonyms: Dbx1^nlslacZ
• Gene: Dbx1 Location: Chr7:49281247-49286583 bp, - strand Genetic Position: Chr7, 31.44 cM
• Alliance: Dbx1^tm1Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70191
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region (exons 1 through 4) was replaced by a cassette comprised of an nls-lacZ gene and a floxed neo gene. Endogenous transcript and protein were were absent from the spinal cords of homozygous mice. The expression pattern of beta-galactosidse was found to resemble that of the endogenous gene in neural progenitor cells. (J:70191)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dbx1 Mutation: 25 strains or lines available

References

• Original: J:70191 Pierani A, et al., Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. Neuron. 2001 Feb;29(2):367-84
• All: 24 reference(s)