Ggt5^tm1Mwl
Targeted Allele Detail

Summary

• Symbol: Ggt5^tm1Mwl
• Name: gamma-glutamyltransferase 5; targeted mutation 1, Michael W Lieberman
• MGI ID: MGI:2182354
• Synonyms: GGL^-, GGL^tm1
• Gene: Ggt5 Location: Chr10:75425174-75453034 bp, + strand Genetic Position: Chr10, 38.55 cM
• Alliance: Ggt5^tm1Mwl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77691
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 500 bp region of the gene including the TATA box and all of exon 1 was replaced with a PGK-neo cassette via homologous recombination. (J:77691)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ggt5 Mutation: 27 strains or lines available

Notes

AB2.1 embryonic stem cells carrying the Ggtp^tm1Zuk mutation were used for gene targeting as were "wild-type" AB2.1 ES cells.

References

• Original: J:77691 Shi ZZ, et al., Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. Mol Cell Biol. 2001 Aug;21(16):5389-95
• All: 3 reference(s)