Pck1tm1.1Lre
Targeted Allele Detail
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Symbol: |
Pck1tm1.1Lre |
Name: |
phosphoenolpyruvate carboxykinase 1, cytosolic; targeted mutation 1.1, Lea Reshef |
MGI ID: |
MGI:2182394 |
Synonyms: |
PPARE- |
Gene: |
Pck1 Location: Chr2:172994866-173001067 bp, + strand Genetic Position: Chr2, 95.79 cM, cytoband C1-qter
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Alliance: |
Pck1tm1.1Lre page
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Germline Transmission: |
Earliest citation of germline transmission:
J:73977
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: This allele is a derivative of Pck1tm1Lre in which Cre-mediated recombination removed the floxed PGK-neomycin resistance cassette that in the initial allele had replaced part of the adipose tissue-specific part of the promoter. Northern blot analysis of fasted homozygous mutant mice detected mRNA in liver and kidney, no mRNA in white adipose tissue, and a decreased level of mRNA in brown adipose tissue. RT-PCR studies using primers for exon 9 and 10 did not detect transcript in white adispose tissue from fasted homozygous mutant mice.
(J:73977)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pck1 Mutation: |
46 strains or lines available
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Original: |
J:73977 Olswang Y, et al., A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):625-30 |
All: |
4 reference(s) |
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