Tacr1^tm1Sph
Targeted Allele Detail

Summary

• Symbol: Tacr1^tm1Sph
• Name: tachykinin receptor 1; targeted mutation 1, Stephen P Hunt
• MGI ID: MGI:2182395
• Synonyms: NK-1^-, NK1^-
• Gene: Tacr1 Location: Chr6:82379315-82537085 bp, + strand Genetic Position: Chr6, 35.94 cM, cytoband D1
• Alliance: Tacr1^tm1Sph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46629
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by the insertion of a cassette containing an IRES-lacZ gene and MC1-neo gene. A lack of ligand binding, determined by receptor autoradiography, indicated an absence of encoded protein in the brain and spinal cords of homozygous mutant mice. Immunohistochemical analysis, using an antibody raised against the carboxy terminus confirmed the lack of encoded protein. (J:46629)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tacr1 Mutation: 40 strains or lines available

References

• Original: J:46629 De Felipe C, et al., Altered nociception, analgesia and aggression in mice lacking the receptor for substance P [see comments]. Nature. 1998 Mar 26;392(6674):394-7
• All: 47 reference(s)