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Pim1tm1Pwl
Targeted Allele Detail
Summary
Symbol: Pim1tm1Pwl
Name: proviral integration site 1; targeted mutation 1, Peter W Laird
MGI ID: MGI:2182396
Synonyms: Pim1-, Pim1neo59
Gene: Pim1  Location: Chr17:29709759-29715085 bp, + strand  Genetic Position: Chr17, 15.38 cM
Alliance: Pim1tm1Pwl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:15268
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced the promoter region, both transcriptional and translational start sites, and a portion of the coding sequence containing an essential lysine residue in the ATP-binding site of the protein kinase domain. An in vitro autophosphorylation assay showed an absence of phospho-kinase activity in splenocytes obtained from homozygous mutant mice. (J:15268)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pim1 Mutation:  16 strains or lines available
References
Original:  J:15268 Laird PW, et al., In vivo analysis of Pim-1 deficiency. Nucleic Acids Res. 1993 Oct 11;21(20):4750-5
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory