Sp3^tm1Sus
Targeted Allele Detail

Summary

• Symbol: Sp3^tm1Sus
• Name: trans-acting transcription factor 3; targeted mutation 1, Guntram Suske
• MGI ID: MGI:2182438
• Synonyms: Sp3-
• Gene: Sp3 Location: Chr2:72766774-72810790 bp, - strand Genetic Position: Chr2, 43.35 cM, cytoband C3
• Alliance: Sp3^tm1Sus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60658
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which encodes the glutamine-rich activation domain, was replaced with a cassette containing an IRES-lacZ-neo fusion gene, adjoined to a splice acceptor site. The three isoforms produced from the endogenous allele were undetected in homozygous mutant mice by Western blot analysis of nuclear extracts. (J:60658)

Expression

In Mice Carrying this Mutation:	49 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sp3 Mutation: 64 strains or lines available

References

• Original: J:60658 Bouwman P, et al., Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J. 2000 Feb 15;19(4):655-61
• All: 10 reference(s)