Dmtf1^tm1Cjs
Targeted Allele Detail

Summary

• Symbol: Dmtf1^tm1Cjs
• Name: cyclin D binding myb like transcription factor 1; targeted mutation 1, Charles J Sherr
• MGI ID: MGI:2182441
• Synonyms: DMP1^-
• Gene: Dmtf1 Location: Chr5:9168868-9211782 bp, - strand Genetic Position: Chr5, 3.69 cM, cytoband A2-A3
• Alliance: Dmtf1^tm1Cjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63444
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exons encoding residues involved in DNA-binding were disrupted by the insertion of a 1.0kb neomycin selection cassette. Western blot analysis using antibodies raised against the carboxy terminal and the Myb-repeat domain showed an absence of encoded protein in homozygous mutant mice. (J:63444)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dmtf1^tm1Cjs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Dmtf1 Mutation: 83 strains or lines available

References

• Original: J:63444 Inoue K, et al., Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. Genes Dev. 2000 Jul 15;14(14):1797-809
• All: 7 reference(s)