Nppc^tm1Yog
Targeted Allele Detail

Summary

• Symbol: Nppc^tm1Yog
• Name: natriuretic peptide type C; targeted mutation 1, Yoshihiro Ogawa
• MGI ID: MGI:2182456
• Synonyms: Nppc-
• Gene: Nppc Location: Chr1:86594015-86598295 bp, - strand Genetic Position: Chr1, 43.98 cM
• Alliance: Nppc^tm1Yog page

Dwarfism in Nppc^tm1Yog/Nppc^tm1Yog mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75620
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2, which contain the entire coding sequence, were replaced with a neomycin resistance gene via homologous recombination. RNase protection assays demonstrated the absence of gene expression in various tissues from homozygous mutant animals. (J:75620)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nppc Mutation: 12 strains or lines available

References

• Original: J:75620 Chusho H, et al., Dwarfism and early death in mice lacking C-type natriuretic peptide. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4016-21
• All: 4 reference(s)