Kcnj10^tm1Lst
Targeted Allele Detail

Summary

• Symbol: Kcnj10^tm1Lst
• Name: potassium inwardly-rectifying channel, subfamily J, member 10; targeted mutation 1, Henry A Lester
• MGI ID: MGI:2182467
• Synonyms: Kcnj10^tm1Pkj, Kir4.1-
• Gene: Kcnj10 Location: Chr1:172168777-172201652 bp, + strand Genetic Position: Chr1, 79.69 cM
• Alliance: Kcnj10^tm1Lst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63635
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding exon of the gene encoding amino acids 33-266, which includes part of the C-terminus and putative transmembrane domains, was replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of retinas from homozygous mutant animals did not detect gene expression. (J:63635)

Disease models

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnj10 Mutation: 28 strains or lines available

References

• Original: J:63635 Kofuji P, et al., Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. J Neurosci. 2000 Aug 1;20(15):5733-40
• All: 21 reference(s)