Brca1^tm2.1Cxd
Targeted Allele Detail

Summary

• Symbol: Brca1^tm2.1Cxd
• Name: breast cancer 1, early onset; targeted mutation 2.1, Chu-Xia Deng
• MGI ID: MGI:2182470
• Synonyms: Brca1^delta11, Brca1^deltaexon11, Brca^delta11
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm2.1Cxd page

Exencephaly and growth retardation in Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Gadd45a^tm1Ajf/Gadd45a^tm1Ajf embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70271
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele, lacking exon 11, was generated by crossing mice heterozygous for Brca1^tm2Cxd with transgenic mice expressing the cre recombinase gene via the EIIa promoter which is active in germ cells. Northern blot analysis of homozygous mutant embryos indicated an absence of full length transcript. Transcript lacking exon 11 was detected in both wild-type and mutant embryos, though the levels were increased in homozygous mutant embyros. (J:70271)

Expression

In Mice Carrying this Mutation:	13 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm2.1Cxd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:70271 Xu X, et al., Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001 Jul;28(3):266-71
• All: 30 reference(s)