Gast^tm1Tcw
Targeted Allele Detail

Summary

• Symbol: Gast^tm1Tcw
• Name: gastrin; targeted mutation 1, Timothy C Wang
• MGI ID: MGI:2182565
• Synonyms: Gas-KO, gatrin -
• Gene: Gast Location: Chr11:100225233-100227822 bp, + strand Genetic Position: Chr11, 63.46 cM
• Alliance: Gast^tm1Tcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43358
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis using an exon 2 probe. (J:43358)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gast Mutation: 18 strains or lines available

References

• Original: J:43358 Koh TJ, et al., Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology. 1997 Sep;113(3):1015-25
• All: 14 reference(s)