Tfap2c^tm1Will
Targeted Allele Detail

Summary

• Symbol: Tfap2c^tm1Will
• Name: transcription factor AP-2, gamma; targeted mutation 1, Trevor Williams
• MGI ID: MGI:2182570
• Synonyms: Tcfap2c^-
• Gene: Tfap2c Location: Chr2:172391513-172400542 bp, + strand Genetic Position: Chr2, 94.87 cM, cytoband H3-H4
• Alliance: Tfap2c^tm1Will page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76369
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 300 bp region of the gene, including the 5' portion of exon 7 encoding the DNA binding domain, was replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant embryos were identified by PCR genotyping at 7.5 dpc. (J:76369)

Expression

In Mice Carrying this Mutation:	14 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2c Mutation: 28 strains or lines available

References

• Original: J:76369 Auman HJ, et al., Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development. 2002 Jun;129(11):2733-47
• All: 3 reference(s)