Efna5^tm1Ddmo
Targeted Allele Detail

Summary

• Symbol: Efna5^tm1Ddmo
• Name: ephrin A5; targeted mutation 1, Dennis D M O'Leary
• MGI ID: MGI:2182573
• Synonyms: A5^-, eA5KO, Efna5^-, ephrin-A5^-
• Gene: Efna5 Location: Chr17:62911179-63188312 bp, - strand Genetic Position: Chr17, 32.57 cM
• Alliance: Efna5^tm1Ddmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45896
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced sequence encoding amino acids 42 through 129 as well as a 5' splice acceptor. RT-PCR analysis showed an absence of transcript in homozygous mutant mice. (J:45896)

Disease models

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Efna5 Mutation: 28 strains or lines available

References

• Original: J:45896 Frisen J, et al., Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 1998 Feb;20(2):235-43
• All: 57 reference(s)