Lhx8^tm1Lmgd
Targeted Allele Detail

Summary

• Symbol: Lhx8^tm1Lmgd
• Name: LIM homeobox protein 8; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
• MGI ID: MGI:2182594
• Synonyms: Lhx8^-
• Gene: Lhx8 Location: Chr3:154011925-154036190 bp, - strand Genetic Position: Chr3, 79.12 cM, cytoband H3-H4
• Alliance: Lhx8^tm1Lmgd page

H&E staining of coronal palatal region sections of Lhx8^tm1Lmgd/Lhx8^tm1Lmgd and wild-type embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59082
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 4 through 6 were replaced with a neomycin selection cassette. (J:59082)

Expression

In Mice Carrying this Mutation:	60 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx8 Mutation: 25 strains or lines available

References

• Original: J:59082 Zhao Y, et al., Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15002-6
• All: 10 reference(s)