Rfng^tm1Grid
Targeted Allele Detail

Summary

• Symbol: Rfng^tm1Grid
• Name: RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1, Tom Gridley
• MGI ID: MGI:2182609
• Synonyms: Rfng^dl
• Gene: Rfng Location: Chr11:120671572-120675033 bp, - strand Genetic Position: Chr11, 84.53 cM
• Alliance: Rfng^tm1Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77247
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced genomic sequence encoding amino acids 53 through 332 (the carboxy terminus) of the encoded protein. The deletion includes all the coding sequence for the mature, processed form of the protein. Northern blot analysis revealed that no transcripts expressed from this gene were present in RNA derived from homozygous mice. (J:77247)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfng Mutation: 15 strains or lines available

References

• Original: J:77247 Zhang N, et al., Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis. 2002 May;33(1):21-8
• All: 6 reference(s)