Zfpm2^tm1Jml
Targeted Allele Detail

Summary

• Symbol: Zfpm2^tm1Jml
• Name: zinc finger protein, multitype 2; targeted mutation 1, Jeffrey M Leiden
• MGI ID: MGI:2182616
• Synonyms: Fog-2^-, Zfpm2^-
• Gene: Zfpm2 Location: Chr15:40518438-40967988 bp, + strand Genetic Position: Chr15, 15.74 cM, cytoband C
• Alliance: Zfpm2^tm1Jml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63121
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of exons 6 and 7 was replaced with a neomycin selection cassette. The replaced region encoded all zinc fingers of the encoded protein. Western blot analysis of homozygous mutant embryonic tissue showed an absence of protein. (J:63121)

Disease models

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfpm2 Mutation: 47 strains or lines available

References

• Original: J:63121 Svensson EC, et al., A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat Genet. 2000 Jul;25(3):353-6
• All: 4 reference(s)