Hdc^tm1Nagy
Targeted Allele Detail

Summary

• Symbol: Hdc^tm1Nagy
• Name: histidine decarboxylase; targeted mutation 1, Andras Nagy
• MGI ID: MGI:2182618
• Synonyms: HDC^-, HDC^delta6-8, HDC KO
• Gene: Hdc Location: Chr2:126435587-126461219 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband E5-G
• Alliance: Hdc^tm1Nagy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70702
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of the gene from intron 5 to exon 9 was replaced with a PGK-neo cassette via homologous recombination resulting in the deletion of the coenzyme binding site encoded by exon 8. Northern blot analysis of kidneys from homozygous mutant animals verified the absence of gene expression. (J:70702)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdc Mutation: 53 strains or lines available

References

• Original: J:70702 Ohtsu H, et al., Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett. 2001 Jul 27;502(1-2):53-6
• All: 116 reference(s)