Efnb2tm3.1Kln
Targeted Allele Detail
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Symbol: |
Efnb2tm3.1Kln |
Name: |
ephrin B2; targeted mutation 3.1, Rudiger Klein |
MGI ID: |
MGI:2182632 |
Synonyms: |
ephrinB2deltaC |
Gene: |
Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
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Alliance: |
Efnb2tm3.1Kln page
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Germline Transmission: |
Earliest citation of germline transmission:
J:67296
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted |
Mutation: |
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Insertion
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Mutation details: Mice heterozygous for Efnb2tm3Kln were bred with mice expressing a cre recombinase transgene, resulting in the excision of the floxed neo gene. The inserted cDNA encoding the truncated protein lacking 66 residues of carboxy terminal region and containing a hemagglutinin (HA) epitope tag, was left intact. The expression pattern of the targeted allele was determined to resemble that of the wild-type allele via in situ hybridization. Analysis using modified receptors showed localization to the cell surface. Production of protein with a reduced molecular weight was verified by immunoblotting with an anti-HA antibody.
(J:67296)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Efnb2 Mutation: |
29 strains or lines available
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Original: |
J:67296 Adams RH, et al., The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell. 2001 Jan 12;104(1):57-69 |
All: |
1 reference(s) |
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