Lbx1^tm1Gld
Targeted Allele Detail

Summary

• Symbol: Lbx1^tm1Gld
• Name: ladybird homeobox 1; targeted mutation 1, Martyn Goulding
• MGI ID: MGI:2182635
• Synonyms: Lbx1^-, Lbx1^GFP, Lbx1GFP(neo)
• Gene: Lbx1 Location: Chr19:45221123-45224251 bp, - strand Genetic Position: Chr19, 38.61 cM, cytoband D
• Alliance: Lbx1^tm1Gld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56498
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A GFP reporter gene was introduced in frame into to exon 1 at amino acid 62 followed by a loxP-flanked PGK-neo cassette via homologous recombination. The insertion causes a frameshift in the homeobox of the gene. Homozygous mutant newborn animals did not express protein product. (J:56498)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lbx1 Mutation: 13 strains or lines available

References

• Original: J:56498 Gross MK, et al., Lbx1 is required for muscle precursor migration along a lateral pathway into the limb. Development. 2000 Jan;127(2):413-24
• All: 13 reference(s)