Aff2^tm1Dln
Targeted Allele Detail

Summary

• Symbol: Aff2^tm1Dln
• Name: AF4/FMR2 family, member 2; targeted mutation 1, David L Nelson
• MGI ID: MGI:2182641
• Synonyms: Fmr2 KO
• Gene: Aff2 Location: ChrX:68403900-68911643 bp, + strand Genetic Position: ChrX, 35.53 cM, cytoband A5
• Alliance: Aff2^tm1Dln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76005
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacing part of exon 1 with a lacZ-PGK-neo cassette via homologous recombination resulting in fusion of the lacZ gene 16 bp upstream of the ATG start codon. Gene expression was absent in homozygous mutant animals as shown by RT-PCR analysis using different sets of primers to the gene. (J:76005)

Expression

In Mice Carrying this Mutation:	34 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aff2 Mutation: 16 strains or lines available

References

• Original: J:76005 Gu Y, et al., Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice. J Neurosci. 2002 Apr 1;22(7):2753-63
• All: 1 reference(s)