Fkbp1b^tm1Syf
Targeted Allele Detail

Summary

• Symbol: Fkbp1b^tm1Syf
• Name: FK506 binding protein 1b; targeted mutation 1, Sidney Fleischer
• MGI ID: MGI:2182644
• Synonyms: FKBP12.6^-
• Gene: Fkbp1b Location: Chr12:4883174-4891591 bp, - strand Genetic Position: Chr12, 2.09 cM
• Alliance: Fkbp1b^tm1Syf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75646
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, which encodes binding sites for Ryr2, FK506, and calcineurin, was replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in hearts from homozygous mutant animals as demonstrated by RT-PCR analysis. (J:75646)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp1b Mutation: 14 strains or lines available

References

• Original: J:75646 Xin HB, et al., Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature. 2002 Mar 21;416(6878):334-8
• All: 15 reference(s)