Eif4g2^tm1Yam
Targeted Allele Detail

Summary

• Symbol: Eif4g2^tm1Yam
• Name: eukaryotic translation initiation factor 4, gamma 2; targeted mutation 1, Shinya Yamanaka
• MGI ID: MGI:2182646
• Synonyms: NAT1^-
• Gene: Eif4g2 Location: Chr7:110667192-110682237 bp, - strand Genetic Position: Chr7, 58.0 cM
• Alliance: Eif4g2^tm1Yam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77324
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neomycin selection cassette. Northern blot analysis of total RNA obtained from homozygous mutant ES cells showed an absence of transcript. Transcript levels were reduced by approximately 50% in heterozygous adult mice. (J:77324)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif4g2 Mutation: 55 strains or lines available

References

• Original: J:77324 Yamanaka S, et al., Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J. 2000 Oct 16;19(20):5533-41
• All: 1 reference(s)