Traf4^tm1Mrio
Targeted Allele Detail

Summary

• Symbol: Traf4^tm1Mrio
• Name: TNF receptor associated factor 4; targeted mutation 1, Marie-Christine Rio
• MGI ID: MGI:2182705
• Synonyms: Traf4^-/-
• Gene: Traf4 Location: Chr11:78049325-78056415 bp, - strand Genetic Position: Chr11, 46.74 cM, cytoband B5-C
• Alliance: Traf4^tm1Mrio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76067
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 4 and all of exons 5-7 were replaced with a neomycin resistance gene via homologous recombination resulting in deletion of the last zinc finger domain and the entire TRAF domain. Absence of gene expression in homozygous mutants was verified by Western blot analysis of mouse embryonic fibroblast (MEFs) derived from E12.5 embyros. (J:76067)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf4 Mutation: 37 strains or lines available

References

• Original: J:76067 Regnier CH, et al., Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5585-90
• All: 3 reference(s)