Tmie^sr-J
Spontaneous Allele Detail

Summary

• Symbol: Tmie^sr-J
• Name: transmembrane inner ear; spinner Jackson
• MGI ID: MGI:2182706
• Synonyms: sr^J
• Gene: Tmie Location: Chr9:110694755-110709141 bp, - strand Genetic Position: Chr9, 60.79 cM
• Alliance: Tmie^sr-J page

Mutation origin

• Strain of Origin: BXA4/PgnJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A single nucleotide C-toT substitution in exon 5 produced a nonsense mutation at arginine codon 97 (p.R97*) that will prevent expression of the majority of the C-terminal charged domain. (J:78124)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmie Mutation: 15 strains or lines available

References

• Original: J:78124 Mitchem KL, et al., Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6. Hum Mol Genet. 2002 Aug 1;11(16):1887-98
• All: 2 reference(s)