Il21r^tm1Day
Targeted Allele Detail

Summary

• Symbol: Il21r^tm1Day
• Name: interleukin 21 receptor; targeted mutation 1, Debra A Young
• MGI ID: MGI:2182707
• Synonyms: IL-21R^-
• Gene: Il21r Location: Chr7:125202601-125232742 bp, + strand Genetic Position: Chr7, 68.98 cM, cytoband F4
• Alliance: Il21r^tm1Day page

Impaired allergic skin inflammation and systemic response to epicutaneous sensitization in Il21r^tm1Day/Il21r^tm1Day mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76043
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression was verified by PCR of total RNA from homozygous mutant animals. (J:76043)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il21r Mutation: 42 strains or lines available

Notes

ES cell line = J12.

References

• Original: J:76043 Kasaian MT, et al., IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation. A Mediator of the Transition from Innate to Adaptive Immunity. Immunity. 2002 Apr;16(4):559-69
• All: 26 reference(s)