Ets1^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Ets1^tm1Fwa
• Name: E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:2182735
• Synonyms: Ets-1^-, Ets-1^d
• Gene: Ets1 Location: Chr9:32547517-32669116 bp, + strand Genetic Position: Chr9, 17.97 cM
• Alliance: Ets1^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29736
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 and 9, encoding the DNA-binding domain comprised of 110 carboxy terminal amino acids, were replaced by a PGK-neo cassette. An absence of transcript was determined in homozygous mutant mice via Northern blot analysis. (J:29736)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ets1 Mutation: 28 strains or lines available

References

• Original: J:29736 Bories JC, et al., Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature. 1995 Oct 19;377(6550):635-8
• All: 7 reference(s)