Gadd45g^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Gadd45g^tm1Flv
• Name: growth arrest and DNA-damage-inducible 45 gamma; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:2182738
• Synonyms: GADD45gamma^-
• Gene: Gadd45g Location: Chr13:52000714-52002504 bp, + strand Genetic Position: Chr13, 26.36 cM, cytoband A5-B
• Alliance: Gadd45g^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69475
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 and part of exon 3, which encode amino acids 92-159 that are involved in interaction with Map3k4, were replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis of IL-2 activated T cells from homozygous mutant animals showed no detectable gene expression. (J:69475)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gadd45g Mutation: 11 strains or lines available

References

• Original: J:69475 Lu B, et al., GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity. 2001 May;14(5):583-90
• All: 9 reference(s)